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(英汉对照)分子生物学-- 名词解释

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发表于 2009-6-5 11:42 | 只看该作者 回帖奖励 |倒序浏览 |阅读模式
α helix                α螺旋       
A helical secondary structure in proteins.
Pl. α helices.                蛋白质中一种螺旋形的二级结构。复数:α helices。       

α-amanitin                α鹅膏蕈碱       
A toxin that inhibits the three eukaryotic RNA polymerases to different extents.  Name derives from mushroom of genus Amanita in which toxin is found.                一种能不同程度地抑制三种真核生物RNA聚合酶的毒素。名称来自于产生此毒素的Amanita属蘑菇。       

β-galactosidase                β-半乳糖苷酶       
Enzyme that cleaves lactose into galactose and glucose.  Name origin: the bond cut by this enzyme is called a β-galactosidic bond.                将乳糖分解为半乳糖和葡萄糖的酶。名称来源:该酶切割的键称为β-半乳糖苷键。       

β sheet                β折叠       
A secondary structure in proteins, relatively flat and formed hydrogen bonding between two parallel or anti-parallel stretches of polypeptide.                蛋白质的一种二级结构,相对平坦,在两条平行的或反向平行的肽段之间形成氢键。       

σ subunit                σ亚基       
Component of prokaryotic RNA polymerase holoenzyme. Required for recognition of promoters.                原核生物RNA聚合酶全酶的组成成分。在启动子识别中需要。       

ρ-dependent termination                ρ依赖型终止       
A form of transcription termination in prokaryotes that depends on the protein ρ as well as on sequences in the DNA/RNA.                原核生物中的一种转录终止方式,依赖于ρ蛋白和DNA/RNA序列引起转录终止。       

─10 box                ─10框       
Common promoter element in E. coli.  Named for its location approximately 10 bases upstream of the transcription start site.                大肠杆菌中常见的启动子元件。由于它位于转录起始为点上游约10个碱基处而得名。       

3’5’ exonuclease activity                3’5’外切核酸酶活性       
Function of DNA polymerases.  Allows 3’5’  removal of incorrect nucleotides after polymerization.  See also exonuclease.                DNA聚合酶的活性。允许在聚合反应后以3’5’方向去除不正确的核苷酸。请参照‘exonuclease’。       

30nm fiber                30nm纤维       
An higher-level structure of chromatin.  The elongated structure has a width of approximately 30nm.                一种染色质的高级结构。其延长的结构宽度大约是30nm。       

30S initiation complex                30S起始复合体       
In prokaryotes, complex of mRNA, 30S ribosomal subunit, and initiator tRNA placed at the start codon.                是原核生物中由mRNA、30S核糖体亚基和起始tRNA在起始密码子位置组成的复合体。       

─35 box                ─35框       
Common promoter element in E. coli.  Named for its location approximately 35 bases upstream of the transcription start site.                大肠杆菌中常见的启动子元件。由于它位于转录起始为点上游约35个碱基处而得名。       

5’3’ exonuclease activity                5’3’外切核酸酶活性       
Function of DNA polymerase I in prokaryotes.  Allows for removal of nucleotides in the direction of synthesis.  Often used for removal of RNA primers.                原核生物中DNA聚合酶I的一种功能。允许以DNA合成方向去除核苷酸。常在去除RNA引物中使用。       

5-bromouracil (BU)                5-溴尿嘧啶(BU)       
Mutagenic base analogue.  Resembles thymine, but easily interconverts to tautomeric form that pairs with guanine. Structure resembles uracil with an attached bromine group.                具有诱变性的碱基类似物。与胸腺嘧啶相似,但很容易转换成与鸟嘌呤配对的互变异构形式。带有溴基团的结构与尿嘧啶相似。       

A (aminoacyl) site                A(氨酰基)位       
First site on the ribosome to which tRNAs bind, bringing new amino acids.  Named after the acyl bond that attaches amino acids to tRNA .                带有新氨基酸的tRNA与核糖体结合的第一个位置。根据氨基酸连接到tRNA上的酰基键命名。       

AI editing                AI编辑       
A form of post-transcriptional modification to mRNA in eukaryotes in which adenine is deaminated to form inosine, an unusual base.                真核生物中对mRNA进行转录后修饰的一种形式,修饰时将腺嘌呤脱氨基形成次黄苷,次黄苷是一种非普通碱基。       

Acetylation                乙酰化作用       
The addition of an acetyl group to a molecule.                将一个乙酰基加到某个分子上的过程。       

Aconitase                顺乌头酸酶       
Protein that regulates iron metabolism.  Controls mRNA stability and translatability for transferrin and ferritin, respectively.                调控铁代谢的蛋白质。分别控制运铁蛋白和铁蛋白的稳定性和可转译性。       

Activators                激活蛋白       
Proteins that increase transcription of a gene.                促进基因转录的蛋白质。       

Active site                活性位点       
Site on an enzyme that is directly responsible for catalyzing reactions.                酶分子中直接负责催化反应的位点。       

Affinity chromatography                亲和层析       
A kind of column chromatography technique. The column is packed with molecules that bind to a specific subset of proteins.  Affinity = attraction.                  柱层析技术的一种。柱中用能与一组特殊的蛋白质结合的分子填充。亲和 = 吸引。       

Alkyl group                烷基       
A class of chemical groups composed of carbon and hydrogen.  Examples: methyl group (─CH3) and ethyl group (─CH2CH3).                由碳和氢组成的一类化学基团。例如:甲基(─CH3)和乙基(─CH2CH3)。       

Alleles                等位基因       
Versions of the same gene that differ slightly in function and sequence.                相同基因的不同版本,它们之间在功能和序列上稍有不同。       

Allosteric regulation                别构调节       
Form of regulation in which a small molecule binds to a regulatory site on a protein, causing a structural and functional change at the active site.  ‘Steric’ is related to the word ‘structure’.                调节的一种形式,通过一个小分子结合到蛋白质的调节位点而引起其活性位点结构和功能的改变。‘steric’(空间的)一词与‘structure’(结构)有联系。       

Alternative polyadenylation                可变聚腺苷酸化       
The ability to make mRNAs of varying sizes from one coding region, by altering the site of pre-mRNA cleavage and polyadenylation.  Can alter protein size and properties of the mRNA, such as stability.                通过改变前体mRNA的切割位点和聚腺苷酸化位点而从一个编码区产生不同大小mRNA的能力。能改变蛋白质分子的大小和mRNA的性质(如稳定性)。       

Alternative splicing                可变剪接       
The ability to make various proteins from one coding region by choosing between the inclusion/exclusion of certain introns and exons.                通过选择包含或不包含某些内含子和外显子而从一个编码区产生不同蛋白质的能力。       

Ames test                埃姆斯测验法       
Technique to assess the mutagenic potential of a chemical.                用来评价化学物质是否具有潜在诱变性的技术。       

Amino acids                氨基酸       
Small molecules that can be polymerized to form proteins.  Name derives from the presence of an amino group as well as an acidic carboxyl group.                能聚合形成蛋白质的小分子。名称来自于它们所带的氨基以及酸性的羧基。       

Amino group                氨基       
A chemical group comprising nitrogen bound to two hydrogen atoms.                由氮原子与两个氢原子结合形成的化学基团。       

Aminoacyl-tRNA synthetase                氨酰-tRNA合成酶       
A protein that matches tRNAs with the correct amino acid.  Name origin: enzyme synthesizes the acyl bond that joins amino acids to tRNAs.                一种将tRNA与正确的氨基酸匹配的蛋白质。名称来源:酶合成了将氨基酸连接到tRNA上去的酰基。       

Anticodon                反密码子       
Three base sequence in a tRNA that binds to one or more codons.  The prefix ‘anti-’ here means ‘opposite’ or ‘complementary.’                tRNA上能与一个或多个密码子结合的三碱基序列。前缀 ‘anti-’在这儿的意思是‘相反的’或‘互补的’。       

Anti-parallel                反向平行的       
Two strands that are parallel but oriented in the opposite direction.  Often used to describe the orientation of strands in a DNA molecule relative to each other.                两条平行但方向相反的链。常用来描述DNA分子中的链相对于各自的方向。       

Ara operon                ara操纵子       
Operon containing genes that metabolize the sugar arabinose.                含有阿拉伯糖代谢基因的操纵子。       

Attenuation                衰减作用       
A mechanism in the trp operon to ensure that genes are not transcribed in the presence of tryptophan.                trp操纵子中用于确保当色氨酸存在时基因不被转录的一种机理。       

Attenuator                衰减子       
Transcribed sequence just downstream of the trp operon promoter that is central to the attenuation mechanism.  Can form a terminating hairpin structure that stops transcription of the operon.                紧接在trp操纵子的启动子之后转录出来的序列,对衰减作用机理很重要。能形成终止型发夹结构而使在操纵子进行的转录停止。       

AU-rich element (ARE)                富含AU元件(ARE)       
Sequence in the 3’UTR of certain eukaryotic mRNAs that is involved in regulation of mRNA stability.  Named for prevalence of A and U bases in the sequence.                在调节mRNA稳定性中起作用的一些真核生物mRNA 3’UTR序列。因序列中含有许多A和U而得名。       

Autonomously replicating sequence
(ARS)                自主复制序列(ARS)       
An origin of replication in yeast.  Name origin: pieces of DNA containing this sequence are able to replicate autonomously, meaning even if they are not part of a chromosome.                酵母中的一种复制起点。名称来源:含有此序列的DN**段即使不是染色体的一部分也能够自主地进行复制。       

Basal transcription                基础转录       
The low rate of transcription that occurs in eukaryotes if only the pre-initiation complex is present (without activators).  Basal ~ base = a low part.                真核生物中如果只有前起始复合体存在(没有激活蛋白)的情况下所发生的低速率的转录。基础 ~ 基底 = 少量。       

Base analogues                碱基类似物       
Molecules that resemble DNA bases in structure and can be incorporated into DNA.  ‘Analogues’ = two things that resemble each other.  Analogue ~ analogy.                结构上与DNA碱基类似的分子,能被整合到DNA中。‘类似物’ = 两种互相相像的事物。类似物 ~ 类似。       

Base excision repair (BER)                碱基切除修复(BER)       
DNA damage repair pathway usually used to fix common damage to DNA bases.                DNA损伤修复途径,通常用来修复DNA碱基的普通损伤。       

Base pair                碱基对       
Two complementary nucleotides bound by hydrogen bonds.  Often used to measure the length for DNA.                通过氢键结合在一起的互补的核苷酸。常用来度量DNA的长度。       

Base-stacking                碱基堆积       
Term to describe the placement of base pairs in a DNA molecule.  Base pairs lie in parallel planes one above the other, giving the impression that they are ‘stacked.’                用来描述DNA分子中碱基排布位置的术语。碱基对一个接一个地平放在平行的平面上,产生一种它们是‘堆放’在那里的印象。       

Beads-on-a-string                线珠结构       
Term to describe the lowest level of DNA organization.  Nucleosomes are separated by stretches of naked DNA.                用于描述DNA组织最低一级水平的术语。核小体由裸露的DN**段连接在一起。       

Bi-directional replication                双向复制       
Term to describe DNA replication that proceeds in two opposite directions from an origin of replication.  The prefix ‘bi-’ = ‘two’.                用来描述DNA复制从复制起点开始沿两个相反的方向进行的术语。前缀‘bi-’ = ‘二’。       

Branch migration                分支迁移       
The movement of a Holliday junction that causes different hybridizations between the homologous chromosomes.                指Holliday交叉的移动,它会引起同源染色体不同区段之间发生杂交。       

CU editing                CU编辑       
A form of post-transcriptional modification to mRNA in eukaryotes in which cytosine is deaminated to form uracil.                一种形式的真核生物转录后修饰作用,修饰时将胞嘧啶脱氨基形成尿嘧啶。       

Capping                加帽       
Post-transcriptional modification in which a derivative of guanosine is attached to the 5’ end of the pre-mRNA.  In normal English, a ‘cap’ is anything that goes on the head of something.  For example, a hat is often called a ‘cap.’                   将鸟嘌呤核苷的衍生物加到前体mRNA 5’端上去的转录后修饰作用。在日常英语中,‘cap’(帽、盖)指放到某些事物头上的任何东西。例如,有沿帽常被叫做‘cap’。       

Carboxyl group                羧基       
Acidic chemical group in which a carbon atom is bound to two oxygen atoms.  Name origin: the group contains carbon and oxygen.                一个碳原子连接到两个氧原子上形成的酸性化学基团。名称来源:该基团含有carbon(碳)和oxygen(氧)。       

Catabolite activator protein (CAP)                代谢物激活蛋白(CAP)       
Protein in prokaryotes that responds to glucose/cAMP concentration to activate transcription.   Used to enhance transcription of the lac and ara operon genes, which produce proteins involved in catabolism.                原核生物中对葡萄糖/cAMP浓度进行响应而激活转录的蛋白质。用于增强lac和ara操纵子基因的转录,产生的蛋白在分解代谢中起作用。

[ 本帖最后由 mao44 于 2009-6-6 13:08 编辑 ]
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    Heterochromatin                异染色质       
    Regions of DNA tightly packaged with proteins, usually does not contain genes to be expressed.                与蛋白质紧密包装在一起的DNA区域,通常没有需要表达的基因。       

    Heterodimerization                异源二聚化作用       
    Formation of dimers between two different subunits.  The prefix ‘hetero-’ = different.                两个不同亚基之间形成二聚体的过程。前缀‘hetero-’ = 不同的。       

    Heteroduplex  joint                异源双链接头       
    Site on a chromosome, produced after homologous recombination, where a region of DNA from one chromosome meets a region from a different chromosome.  At the joint, single-stranded DNAs from the different chromosomes are hybridized.  The prefix ‘hetero-’ = different.                染色体上由同源重组产生的位点,其中来自一条染色体的DNA区域与来自另一条染色体的区域相遇。在接头处,来自不同染色体的单链DNA杂交在一起。前缀‘hetero-’ = 不同的。       

    Histone code                组蛋白密码       
    Combinations of covalent modifications on histones that have a functional significance and are recognized by proteins.                在组蛋白上发生的共价修饰组合,具有功能意义,能被蛋白质识别。       

    Histone tails                组蛋白尾       
    Long unstructured ends of histones that stick out from the nucleosome.  Can bind to other DNA and to other histones, and can be covalently modified.                从核小体中伸出的组蛋白非结构化长末端。能与其它DNA和其它组蛋白结合,能被共价修饰。       

    Histones                组蛋白       
    Proteins around which DNA is wrapped to organize it and regulate transcription.                用于缠绕DNA以组织DNA并调控转录的蛋白质。       

    Holliday junctions                Holliday交叉       
    Structure formed during homologous recombination connection of single strands of one chromosome to the other chromosome.  Named after a scientist called Holliday.                在同源重组中一条染色体的单链与另一条染色体的单链连接形成的结构。根据科学家的名字Holliday命名。       

    Homeodomain                同源异形域       
    DNA-binding domain, found in many eukaryotic proteins involved in organismal development.                DNA结合域,在许多真核生物中发现,在生物发育中起作用。       

    Homologous chromosomes                同源染色体       
    Chromosomes that are not identical, but have the same set of genes. The prefix ‘homo-’ = ‘same’.                不是完全相同但具有同样一套基因的染色体。前缀‘homo-’ = ‘相同的’。       

    Homologous recombination                同源重组       
    Recombination between DNA molecules with similar DNA sequences.  The prefix ‘homo-’ = ‘same.’                在具有相似DNA序列的DNA分子之间发生的重组。前缀‘homo-’ = ‘相同的’。       

    Housekeeping genes                持家基因       
    Genes that must be transcribed in all cells, because they have a function that is basic to cell survival.  In normal English, ‘housekeeping’ refers to the daily activities required in a home, like cleaning and cooking.  Housekeeping genes are genes perform the daily activities required in a cell.                在所有细胞中必须被转录的基因,因为它们具有的功能对细胞生存来说是最基本的。在日常英语中,‘housekeeping’指在家里需要做的日常事务。持家基因是那些需要在细胞中执行日常事务的基因。       

    Hybridization                杂交       
    The binding of two strands of nucleic acid.  Hybridization can occur between two different DNA molecules, and between DNA and RNA.                核酸的两条链之间的结合。杂交可以发生在两条不同的DNA分子之间,以及DNA和RNA之间。       

    Hydrogen bonds                氢键       
    Relatively weak interatomic bonds involving hydrogen atoms that are partially positively charged.                相对较弱的原子之间形成的键,由于氢原子上带有部分正电荷而引起。       

    Hydrophobic interaction                疏水相互作用       
    Interaction that occurs between non-polar molecules in the presence of water.  Prefix ‘hydro-’ = ‘water’, and suffix ‘-phobic’ = ‘afraid of’.                当非极性分子被置于水中发生的相互作用。前缀‘hydro-’ = ‘水’,后缀‘-phobic’ = ‘害怕’。       

    Immunoprecipitation                免疫沉淀法       
    Technique in which proteins are isolated by antibodies.  Name origin: antibodies are sometimes called immunoglobulins, because they are active in the immune system.  The technique creates a clump of proteins called a precipitate.                通过抗体对蛋白质进行分离的技术。名称来源:抗体有时称为免疫球蛋白(immunoglobulins),因为它们在免疫系统中很活跃。该技术产生一种蛋白质聚集形成的沉淀。       

    Induced mutations                诱导突变       
    Mutations caused by factors not normally present in the cell.                由通常不是细胞的正常成分引起的突变。       

    Induced-fit                诱导契合       
    A change in the structure of an enzyme’s active site during catalysis.                在催化过程中酶的活性位点结构所发生的改变。       

    Inducer                诱导物       
    A small molecule that binds to a transcription factor, leading to activation of transcription.  May act by preventing a repressor protein from repressing transcription.                与转录因子结合从而激活转录的小分子。可以通过防止阻遏蛋白对转录的阻遏而发挥作用。       

    Initiator tRNA                起始tRNA       
    A specialized tRNA that functions in translation initiation.                在转译起始中起作用的一种特殊tRNA。       

    Initiator (Inr) promoter element                起始子(Inr)启动子元件       
    An element of eukaryotic promoters, involved in initiation of transcription.                在转录起始中起作用的真核启动子元件。       

    Inosine                次黄苷       
    A nitrogenous base.  Sometimes found in tRNA anti-codons, where it has the ability to recognize three different bases at the third position in the codon.                一种含氮碱基。有时出现在tRNA的反密码子中,具有识别位于密码子第三个位置的三个不同碱基的能力。       

    Insertion sequences                插入序列       
    Simple prokaryotic transposons.  They are sequences that insert themselves into random sites on a piece of DNA.                简单的原核生物转座子。它们是一些能使自身插入到一段DNA随机位置中的序列。       

    Insertion/deletion loop (IDL)                插入/缺失环(IDL)       
    Loops caused by strand slippage during DNA replication.  Leading to deletions or insertions, depending on which strand the loop occurs.                在DNA复制过程中由于链滑动而形成的环。能导致缺失或插入突变,依环出现在哪条链而定。       

    Insertions                插入       
    With reference to DNA, the addition of bases into a coding region.                指在DNA编码区增加了碱基。       

    Integrase                整合酶       
    Protein coded by LTR-retrotransposons, similar in function to transposase.  Helps to integrate the transposon into a site on the DNA.                LTR反转录转座子编码的蛋白质,与转座酶功能相似。帮助将转座子整合(integrate)到DNA的位点中。       

    Intercalating agents                嵌入剂       
    Molecules that resemble base pairs in structure and insert between base pairs in DNA, causing insertions and deletions.  The prefix ‘inter-’ = ‘between’.                结构与碱基对相似并能插入到DNA的碱基对之间的分子,能引起插入与缺失突变。前缀‘inter-’ = ‘在······之间’。       

    Internal ribosome entry sequence (IRES)                内部核糖体进入序列(IRES)       
    A sequence in eukaryotic mRNAs that allows ribosomes to begin translation downstream of the normal start codon.                真核mRNA序列中位于正常起始密码子下游、允许核糖体开始转译的区域。       

    Intrinsic termination                内在型终止       
    A transcription termination mechanism in prokaryotes in which the transcribed RNA forms a hairpin loop followed by a string of A’s.  Called ‘intrinsic’ because the RNA alone is able to stop transcription, without help from proteins.                原核生物转录终止的一种机理,终止时转录出来的RNA形成发夹环结构,紧接其后的是一连串A。称之为内在型的原因是因为RNA自身即能终止转录,不需要蛋白质的帮助。       

    Introns                内含子       
    Sequences that do not code for protein that intervene (or interrupt) among coding regions.                 不编码蛋白质并干涉(intervene)或打断(interrupt)编码区的序列。       

    Introns-early theory                内含子早期论       
    Theory that introns were present in early life forms and were retained by eukaryotes, but lost by prokaryotes.                认为内含子在早期生命形式中即存在并被真核生物保留而被原核生物丢失的理论。       

    Introns-late theory                内含子后期论       
    Theory that introns were introduced into eukaryotes after the lineage separated from prokaryotes.                认为内含子是真核生物在与原核生物进化谱系分开以后才开始有的理论。       

    Inversion                倒位       
    When a region of a chromosome becomes rotate, or inverted, in orientation.                一个染色体区域的方向发生旋转或颠倒的现象。       

    Inverted repeats                反向重复序列       
    Sequences that are the same if you take the complement of one and read it backwards.                互补序列从反方向读与它自身相同的序列。       

    Ion-exchange chromatography                离子交换层析       
    A type of column chromatography in which proteins are separated according to charge.  Column is loaded with ions.                根据蛋白质所带电荷的不同而进行分离的一种柱层析技术。层析柱用离子装填。       

    Ionic bonds                离子键       
    An attraction between two ions of opposite charge.                带相反电荷的两个离子之间的引力。       

    Kinases                激酶       
    Proteins that add phosphate groups to other proteins.                将磷酸基团加到其它蛋白质上去的蛋白质。       

    Knockdown                基因敲低       
    The use of RNA interference to eliminate specific mRNAs in the cell.  In colloquial English, ‘knock down’ means to throw something to the floor.                 应用RNA干涉从细胞中去除特殊mRNA的技术。在口头英语中,‘knock down’的意思是:把······丢到地上。       

    Knockout                基因敲除       
    A technique to eliminate the presence of specific gene in an entire organism.  In colloquial English, a ‘knockout’ is when someone is defeated in a fight.                将某个特殊的基因从整个生物中去除的技术。在口头英语中,‘knockout’的意思是:某人被打败。       

    Lac operon                lac操纵子       
    An operon containing genes involved in lactose metabolism.                含有乳糖(lactose)代谢基因的操纵子。       

    Lac repressor                lac阻遏蛋白       
    Repressor protein that regulates the lac operon.                调控lac操纵子的阻遏蛋白。       

    Lactose                乳糖       
    A sugar composed of glucose and galactose.  Often found in milk.  The root ‘lact’ is related to the Latin word for milk.                一种由葡萄糖和半乳糖组成的糖。牛奶中常见。词根‘lact’与拉丁语中的牛奶一词有关。       

    Lactose permease                乳糖渗透酶       
    A protein that brings lactose into the cell.  In other words, it makes the cell permeable to lactose.                一种将乳糖送进细胞的蛋白质。也就是说,它使细胞对乳糖变成可渗透的(permeable)。       

    Lagging strand                后随链       
    The strand that is replicated discontinuously during DNA replication.  In normal English, ‘lagging’ = ‘slower’.  Lagging strand replication is a little bit slower, and less direct, than leading strand replication.                在DNA复制中以不连续方式复制的链。在日常英语中,‘lagging’ = ‘较慢的’。相对于先导链的复制而言,后随链的合成稍微有一点慢而且不那么直接。       

    Lariat                套索       
    An intermediate, looped, structure in splicing.  In normal English, a ‘lariat’ is a loop made out of rope that is used for catching animals.                在剪接中产生的环状中间结构。在日常英语中,‘lariat’指一种用来捕捉动物的环形绳圈。       

    Leading strand                先导链       
    The strand that is replicated continuously in DNA replication.  In normal English, something that is ‘leading’ is ahead of other things.  Indeed, the leading strand is replicated a little more quickly and more directly than the lagging strand.                在DNA复制中连续复制的链。在日常英语中,something that is ‘leading’的意思是:它在其它事物之前。实际上,先导链比后随链复制得稍微快一点而且也更直接。       

    Leaky mutation                渗漏突变       
    A missense point mutation that has an affect on protein function.  In normal English, something ‘leaky’ abnormally allows liquid to pass through.  For example, a cup with a hole at the bottom is a ‘leaky’ cup.  Leaky things are usually slightly broken or damaged.  Likewise, proteins with leaky mutations are slightly damaged.                对蛋白质功能有影响的一种错义点突变。在日常英语中,something ‘leaky’的意思是允许液体以不正常的方式通过。例如,底部有一个洞的杯子是一只漏的(leaky)杯子。漏的东西一般来说是有轻微碎裂或损坏的东西。同样,具有渗漏突变的蛋白质也是被轻微损坏的。
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     楼主| 发表于 2009-6-5 11:45 | 只看该作者

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    Leucine zipper                亮氨酸拉链       
    A DNA-binding domain formed by two α-helices, usually from two different proteins that come together at the DNA.  The helices are held to each other by hydrophobic interaction, as both are lined with leucine amino acids.                一种由两个α螺旋组成的DNA结合域形式,通常由一起来到目标DNA的两种不同蛋白质组成。两个螺旋通过疏水相互作用而保持在一起,因为两者都具有排布成一条线的亮氨酸。       

    Ligand                配体       
    A small molecule that binds to a protein and changes its function.                一种与蛋白质结合并改变蛋白质功能的小分子。       

    Ligase                连接酶       
    An enzyme that repairs single-stranded cuts in DNA.                一种修补DNA单链缺口的酶。       

    Lock-and-key mechanism                锁-钥机理       
    A mechanism in which the active site of the enzyme does not change shape during catalysis. Name origin: when a key fits into a lock, the shape of each component is perfectly suited to accommodate the other, and no change of shape is necessary.                一种在催化反应中酶活性位点形状不发生改变的机理。名称来源:当一把钥匙插进锁中时,每个部分的形状都与其它部分完全匹配,不需要改变任何形状。       

    LTR-retrotransposons                LTR反转录转座子       
    A class of retrotransposons that integrate into DNA using integrase.  Name origin: LTR stands for ‘long terminal repeats’.  These transposons have long repeated sequences at each end.  The term prefix ‘retro-’ = ‘reverse’ or ‘backwards’.  Retrotransposons use reverse transcriptase to make DNA from RNA.  This is backwards from the normal progression of the central dogma.                一类使用整合酶将自身整合进DNA的反转录转座子。名称来源:LTR表示‘long terminal repeats’(长末端重复序列)。这些转座子在两头都有长的重复序列。前缀‘retro-’ = ‘相反的’或‘向后’。反转录转座子使用反转录酶从RNA产生DNA。这与中心法则的正常顺序相反。       

    Macromolecule                大分子       
    A large molecule made by covalently joining smaller molecules.  Prefix ‘macro-’ = large.                 将小分子以共价键连接起来产生大的分子。前缀‘macro-’ = 大的。       

    Major grooves                大沟       
    Indentations on the side of the double helix.  Some of these grooves are large, some are small.  The large grooves are called major grooves.                双螺旋侧面的沟槽。这些沟槽有的大、有的小。大的沟槽叫做大沟。       

    Mass spectrometry                质谱       
    A technique that determines the mass of molecules using a machine.                一种应用仪器测定分子质量的技术。       

    Methyltransferase                甲基转移酶       
    An enzyme that transfers methyl groups from a damaged base onto itself, directly reversing damage to the base.                从一个损伤碱基上将甲基(methyl)转移(transfers)到自己身上的一种酶,能直接逆转损伤碱基的状态。       

    MicroRNA (miRNA)                微小RNA(miRNA)       
    Small hairpin shaped RNAs that regulate mRNA stability and translation.  Prefix ‘micro-’ = very small.                调控mRNA稳定性及其转译的发夹形小RNA分子。前缀‘micro-’ = 很小。       

    Mismatch repair (MMR)                错配修复(MMR)       
    A mechanism for the repair of mismatched bases in a DNA molecule.                一种修复DNA分子中错配碱基的机理。       

    Mismatched base                错配碱基       
    A base pair in which the two bases are not complementary to each other.  Prefix ‘mis-’ = incorrect.  ‘Match’ = put two things together.  Mismatched bases have been incorrectly put together, often by DNA polymerase.                一种两个碱基互相不互补的碱基对。前缀‘mis-’ = 不正确的。‘Match’ = 将两样事物放到一起。错配碱基是被不正确地放到一起的碱基,通常由DNA聚合酶引起。       

    Missense mutation                错义突变       
    A point mutation that causes a change in one amino acid of a protein.  Prefix ‘mis-’ = incorrect.  ‘Sense’ = meaning (in this case).  Missense mutations often give proteins an incorrect meaning, or function.                引起蛋白质中一个氨基酸变化的点突变。前缀‘mis-’ = 不正确的。‘Sense’ = 在这儿的意思是“含义”。错义突变常常赋予蛋白质一种错误的含义或功能。       

    Modules                模块       
    Protein domains that are found in many proteins and are well conserved in evolution.                在许多蛋白质中存在并且在进化中相当保守的蛋白质域。       

    Molecular cloning                分子克隆       
    A technique to isolate a gene and have many copies of it available.  ‘Cloning’ = making identical copies of something.                一种分离基因并获得许多它的拷贝的技术。‘cloning’ = 产生许多……的相同拷贝。       

    Monomer                单体       
    Single molecules that are joined with other molecules to make a larger molecule or polymer.  Prefix ‘mono-’ = ‘one’ or ‘single’.                连接在一起产生更大的分子或聚合体的小分子。前缀‘mono-’ = ‘一个’或‘单个’。       

    Motif                基序       
    A small, basic protein structure that is found in many different proteins.                在许多不同蛋白质中存在的小的、基本的蛋白质结构。       

    mRNA                mRNA       
    Short for ‘messenger’ RNA.  Is the kind of RNA used to copy genetic information in DNA for use by the ribosome.  In other words, it acts as a messenger of genetic information.                信使(messenger)RNA的缩写。是用来从DNA中拷贝遗传信息供核糖体使用的一种RNA。换句话说,它作为遗传信息的信使。       

    mRNA-specific control                mRNA特异性控制       
    A kind of translation control in which the translation of specific mRNAs is regulated, as opposed to all mRNAs.                一种转译控制的种类,它调控的是特殊的mRNA,而不是全部mRNA。       

    Mutation                突变       
    DNA damage that causes a heritable change in the DNA.                使DNA发生可遗传变化的DNA损伤。       

    Negative regulation                负调控       
    With respect to transcription, means that the binding of a protein causes repression of transcription.                关于转录,意思是当一种蛋白质结合上去以后引起转录的阻遏。       

    Nitrogenous base                含氮碱基       
    One or two-ringed molecules that are an important component of nucleic acids.  Each ring has a number of nitrogen atoms.                一种一个环或两个环的分子,是核酸的重要组成部分。每个环有几个氮(nitrogen)原子。       

    Nitrous acid                亚硝酸       
    A mutagenic chemical that causes deamination and conversion of several bases into abnormal bases.                能引起脱氨基和将几种碱基转变成异常碱基的诱变性化学物质。       

    Non-homologous end joining (NHEJ)                非同源末端连接(NHEJ)       
    A form of double-stranded break repair in which broken ends are directly rejoined, without using homologous recombination.                一种双链断裂的修复形式,修复时将断头直接连接起来,不需要进行同源重组。       

    Non-homologous recombination                非同源重组       
    Rearrangement of DNA regions that are not similar (homologous) to each other.                互相不相似的(即不同源的)DNA区域之间的重排。       

    Non-LTR retrotransposons                非LTR反转录转座子       
    see LTR retrotransposons.  Non-LTR retrotransposons do not have long terminal repeats, and integrate into DNA using a completely different mechanism.                参照‘LTR反转录转座子’。非LTR反转录转座子没有长末端重复序列,采用完全不同的机理整合到DNA中。       

    Nonsense mutation                无义突变       
    A point mutation that introduces a stop codon before the normal stop codon of the gene.  In normal English, ‘nonsense’ = something that has no meaning.  The introduction of a stop codon is a serious mutation, and often leads to mRNAs that cannot be transcribed or that make seriously damaged proteins.                在基因的正常终止密码子之前产生一个终止密码子的点突变。在日常英语中,‘nonsense’ = 没有意义的事物。产生终止密码子是一种严重的突变,常常导致mRNA不能被转译或产生严重损坏的蛋白质。       

    Northern blotting                Northern印迹法       
    A technique to identify individual RNA molecules after gel electrophoresis.  Name origin: the word ‘Northern’ here is a play on words.  The first such technique to be developed was for DNA.  It was called a Southern blotting because the scientist who developed the technique was named Southern.  Southern is also a word that indicates direction.  When a similar technique was developed for RNA, scientists wanted to give the technique a similar but different name, so they called it a Northern blotting.  ‘Northern’ is not anybody’s last name, but it is the opposite direction as ‘southern’.                在凝胶电泳后对单个RNA分子进行鉴定的技术。名称来源:‘Northern’在这儿是个双关语。第一种这样的技术是用在DNA上的。它被称为Southern印迹法,因为发展出这一技术的科学家名叫Southern。Southern(南方的)也是一个指方向的词。当在RNA上发展出类似的技术时,科学家想为它取一个类似的、但又不同的名称,所以他们把它叫做Northern印迹法。‘Northern’ 不是任何人的姓,它是‘southern’的对应词。       

    N-terminus                N末端       
    The end of a protein containing a free amino group.  The ‘N-’ derives from the fact that amino groups contain nitrogen.                蛋白质的含有自由氨基的末端。‘N-’来自于氨基中含有氮(nitrogen)这一事实。       

    Nuclear pores                核孔       
    Large protein complexes in the nuclear membrane that allow molecules to pass between the nucleus and the cytoplasm.  A ‘pore’ = a small hole in a surface.                核膜上的大的蛋白质复合体,允许分子在细胞核与细胞质之间通行。‘pore’ = 表面上的小孔。       

    Nucleic acids                核酸       
    Macromolecules that are polymers of nucleotides.  They are acidic because of the phosphodiester bond, and are found in high concentrations in the nuclei of cells.                一种大分子,是核苷酸的聚合物。由于它们含有磷酸二酯键,所以它们是酸性(acidic)的,并且在细胞核(nuclei)中以很高的浓度存在。       

    Nucleosome                核小体       
    A structure with DNA wrapped around a core of histones. In normal English, ‘nuclear’ = ‘core’.                DNA包裹在组蛋白核心外面形成的结构。在日常英语中,‘nuclear’ = ‘核心’。       

    Nucleotide excision repair (NER)                核苷酸切除修复(NER)       
    A kind of excision repair usually used to fix nucleotides that have undergone large or unusual modifications.                一种切除修复方法,通常用来修复经受了大的或不同寻常修饰的核苷酸。       

    Nucleotides                核苷酸       
    Small molecules that can be polymerized to form nucleic acids.                能够聚合形成核酸的小分子。       

    Nucleus                细胞核       
    The compartment of eukaryotic cells that houses most of the DNA.  In normal English, ‘nucleus’ = ‘core’ or ‘center’.  The nucleus of an atom is the small core of protons and neutrons.                为大多数DNA提供停留场所的真核细胞内的隔离空间。在日常英语中,‘nucleus’ = ‘核心’或‘中心’。原子的核是由质子和中子组成的小核心。       

    Okazaki fragments                冈崎片段       
    Individual pieces of newly synthesized DNA created during discontinuous synthesis.  Okazaki is the name of the scientist who discovered these fragments.                在不连续合成中产生的新合成的单独DN**段。冈崎是发现这些片段的科学家的姓名。       

    Operator                操纵基因       
    DNA element in prokaryotes downstream of the promoter.  Binding site for proteins that regulate transcription.  In normal English, an ‘operator’ = somebody who controls a system.                原核生物中位于启动子下游的DNA元件。是转录调控蛋白的结合位点。在日常英语中,‘operator’ = 控制某一系统的人。       

    Operons                操纵子       
    An organization of related genes in which all genes are under the control of one regulatory region and are expressed on one mRNA transcript.                一种相关基因的组织方式,其中所有基因位于一个调控区域的控制之下并且被表达成一个mRNA转录本。       

    OriC                OriC       
    The origin of replication on an E. coli chromosome.                大肠杆菌染色体(chromosome)上复制的起点(origin)。       

    Overexpression                过量表达       
    A technique in which a particular protein is expressed in a cell in large concentrations, over the normal concentration.                一种在细胞中大量表达(expressed)某种特殊蛋白的技术,其表达量超出了(over)正常的浓度。       

    P (petpidyl) site                P(肽基)位       
    Site on a ribosome to which a tRNA moves after being in the A site.  In the P site, the bond that joins the tRNA to a polypeptide is broken, and the polypeptide is rejoined to the tRNA (+ amino acid) in the A site by a peptide bond.                核糖体上的一个位置,是tRNA从A位移出后所处的位置。在P位上,tRNA与多肽链之间的连接被打断,之后此多肽链与A位上的tRNA(+氨基酸)之间形成肽键。       

    Partial diploids                部分二倍体       
    Organisms to which an extra set of certain genes has been added (see diploid).                指一些特殊的生物,其体内的一些基因有额外的一套拷贝(参照‘二倍体’)。       

    Peptide                肽       
    A term often used to denote a small polypeptide.                时常用来说明小多肽的术语。       

    Peptide bond                肽键       
    The bond that connects amino acids in a polypeptide.                在多肽中连接氨基酸的键。       

    Peptidyl transferase                肽基转移酶       
    The enzyme functioning in ribosomes that transfers the polypeptide from the P site tRNA to the A site tRNA (+ amino acid), creating a new peptide bond.                在核糖体中发挥作用的一种酶,它将P位tRNA上的多肽转移(transfer)到A位的tRNA(+氨基酸)上,产生新的肽(peptide)键。       

    Phosphodiester bond                磷酸二酯键       
    A bond joining nucleotides in a nucleic acid.  The bond contains one phosphorous atom, and two ester bonds.  The prefix ‘di-’ = ‘two’.                在核酸中连接核苷酸的键。该键含有一个磷原子和两个酯键。前缀‘di-’ = ‘二’。       

    Photolyase                光解酶       
    Enzyme that directly reverses pyrimidine dimers, which usually are caused by UV light.  Prefix ‘photo’ = ‘light’.                直接逆转嘧啶二聚体突变(通常由UV光线引起)的酶。前缀‘photo’ = ‘光’。       

    Point mutations                点突变       
    Mutations to individual bases in DNA, usually leading to substitution of a base with another base.  In normal English, a ‘point’ = something very small and precisely localized.  Likewise, point mutations only occur to single bases, a very small part of the whole DNA molecule.                DNA中单个碱基的突变,通常造成某个碱基被另一个碱基替换。在日常英语中,‘point’ = 很小、很精确地定位的事物。同样,点突变只发生在单个的碱基上,在整个DNA分子很小的部分上。       

    Poly(A) polymerase                Poly(A)聚合酶       
    Specialized RNA polymerase that adds many adenine nucleotides to the end of pre-mRNAs to form the poly(A) tail.                在前体mRNA的末尾加上许多腺嘌呤核苷酸以形成poly(A)尾的特殊酶。       

    Poly(A) tail                Poly(A)尾       
    A post-transcriptional addition to mRNA in eukaryotes that involves addition of many adenine (A) nucleotides to the 3’ end of the transcript.  Prefix ‘poly-’ = ‘many’.                真核生物在转录后加在mRNA 3’末端后面的许多腺嘌呤(A)核苷酸。前缀‘poly-’ = ‘许多’。       

    Polycistronic mRNA                多顺反子mRNA       
    mRNA in prokaryotes that contains more than one gene to be translated.  Cistron = gene.  Prefix ‘poly-’ = ‘many’ or ‘more than one’.                含有不止一个需转译基因的原核生物mRNA。cistron(顺反子) = 基因。前缀‘poly-’ = ‘许多’或‘不止一个’。       

    Polymerase chain reaction (PCR)                聚合酶链式反应(PCR)       
    A technique used to replicate specific regions of a DNA template many times.  A chain reaction = reaction that grows larger and larger over time.  With each cycle of PCR, the amount of DNA copies produced grows almost exponentially.                一种用来对DNA模板上特殊区域进行许多次复制的技术。链式反应 = 随时间推移变得越来越多的反应。经过每一循环的PCR,产生出的DNA量几乎以指数形式增长。       
                           

    Polymer                聚合物       
    Macromolecule created by linking many smaller molecules.  Prefix ‘poly-’ = ‘many’.  Suffix ‘-mer’ = ‘subunits’ or ‘smaller components’.                通过连接许多小分子而产生出的大分子。前缀‘poly-’ = ‘许多’。  后缀‘-mer’ = ‘亚基’或‘更小的组分’。       

    Polypeptide                多肽       
    A polymer of amino acid connected by peptide bonds.                氨基酸由肽键连接在一起形成的聚合物。       

    Polysome                多核糖体       
    A translation complex in which multiple ribosomes are translating one mRNA at the same time.   Prefix ‘poly-’ = ‘many’ or ‘more than one’.                一种转译复合体,其中有多个核糖体同时在转译同一条mRNA。前缀‘poly-’ = ‘许多’或‘不止一个’。       

    Positive regulation                正调控       
    In reference to transcription, denotes the activation of transcription by binding of a protein.                关于转录,表示通过一种蛋白质的结合而激活转录。       

    Pre-initiation complex                前起始复合体       
    The group of general transcription factors II (TFIIs) and RNA polymerase II that assemble at the promoter of each Class II gene before initiation of transcription.  Prefix ‘pre-’ = ‘before’.                在转录起始前一组通用转录因子II(TFIIs)和RNA聚合酶II在每个II类基因启动子位置组装产生的结构。前缀‘pre-’ = ‘在……之前’。       

    Pre-mRNA                前体mRNA       
    The precursor to a eukaryotic mRNA, which has been transcribed but has not yet undergone post-transcriptional modifications.  Prefix ‘pre-’ = ‘before’.                真核mRNA的前体,已经被转录出来但还没有经过转录后修饰。前缀‘pre-’ = ‘在……之前’。       

    Pre-replicative complex (Pre-RC)                前复制复合体(Pre-RC)       
    Complex of proteins that mark origins of replication in eukaryotes and initiate replication.  Often forms long before replication begins.  Prefix ‘pre-’ = ‘before’.                真核生物中标明复制起点并启动转录的蛋白质复合体。常常在复制开始前好久就形成了。前缀‘pre-’ = ‘在……之前’。       

    Primary structure                初级结构       
    Amino acid sequence of a protein.  Perhaps termed a ‘structure’ because the sequence is often enough to determine the folded structure of the protein.                蛋白质的氨基酸序列。称之为‘结构’的原因也许是因为这样的序列常常足以决定该蛋白质折叠出的结构。       

    Primary transcript                初级转录物       
    see pre-mRNA.  In normal English, a transcript = a copy of something.  Primary = first.  The primary transcript is the first RNA copy of the DNA, before any modifications have been made.                参照‘pre-mRNA’。在日常英语中,a transcript = 某种事物的拷贝。primary = 第一、首先。初级转录物是DNA的第一个RNA拷贝,是在任何修饰发生前的拷贝。       

    Primase                引发酶       
    The enzyme that adds primers to DNA.                将引物加到DNA上去的酶。       

    Primers                引物       
    Short pieces of RNA that are hybridized to DNA so that DNA polymerase can initiate replication.  Prefix ‘prim-’ = ‘first’.  Primers must be made first, before DNA synthesis can begin.                短的RN**段,与DNA杂交以便DNA聚合酶启动转录。前缀‘prim-’ = ‘第一、首先’。在开始DNA合成前必须先有引物。       

    Processivity                持续合成能力       
    The amount of DNA that DNA polymerase can replicate in one run, before falling off the template.                DNA聚合酶在从模板上脱落前一次能够合成的DNA量的大小。       

    Promoter                启动子       
    DNA element responsible for binding to RNA polymerase (and general transcription factors, in eukaryotes).  Often involved in regulation of transcription.  In normal English, ‘promote’ = to encourage.                负责与RNA聚合酶结合的DNA元件(在真核生物中还负责与通用转录因子的结合)。常常涉及转录调控。在日常英语中,‘promote’ = 鼓励。       

    Proofread                校正       
    The process of rechecking work and correcting errors.  DNA polymerase and RNA polymerase both have some ability to proofread the strands they are synthesizing.                再次检查合成出的产物并更正其中错误的过程。DNA聚合酶和RNA聚合酶都具有一定的校正能力,以防止所合成的链中存在错误。       

    Proteases                蛋白酶       
    Proteins that cut other proteins.                切割其它蛋白质的蛋白质。       

    Protein domain                蛋白质域       
    A region of protein structure that has a specific and isolated function.                具有特殊功能的蛋白质结构中的一个区域。       

    Pull-down assay                下拉分析       
    A technique very similar to affinity chromatography.  A column is packed with a specific protein, and proteins that bind to that protein, directly or via other proteins, are retained in the column.  Called a ‘pull-down’ because all proteins that bind to the target are pulled out of the cell extract.                一种与亲和层析非常相似的技术。层析柱用一种特殊蛋白充填,能与这种蛋白质直接或间接结合的蛋白质被留在了层析柱里。称为‘下拉’是因为所有与目标蛋白结合的蛋白质都从细胞提取物中被拉了出来。       

    Purines                嘌呤       
    Nitrogenous bases containing two rings.                具有两个环的含氮碱基。       

    Pyrimidine dimer                嘧啶二聚体       
    A form of DNA damage in which two adjacent pyrimidines in a DNA strand become covalently bound to each other.  Often caused by UV light.                一种DNA损伤形式,其中DNA链上两个相邻的嘧啶被共价连接到了一起。通常由UV光引起。       

    Pyrimidines                嘧啶       
    Nitrogenous bases containing only one ring.                只含有一个环的含氮碱基。       

    Quaternary structure                四级结构       
    The structure of a protein with multiple subunits.  Quaternary = fourth degree.  This structure is one level or organization higher than tertiary (third degree) structure.                具有多个亚基的蛋白质的结构。quaternary = 第四个等级。这一结构的水平或组织比三级结构高一个等级。       

    R group                R基团       
    The variable chemical group in an amino acid.                氨基酸中一种可变的化学基团。       

    Reading frame                读码框       
    The organization of bases in a coding region into groups of three, marked at the beginning and end by start and stop codons.                编码区中碱基以三个为一组形成的结构,以起始密码子和终止密码子为开始和结束的标志。       

    Recombination                重组       
    General term for a process that changes the order of pieces of DNA, creating new combinations of DNA regions.  Prefix ‘re-’ = ‘again’ or ‘new’.                用于描述DN**段顺序发生改变、产生DNA区域新组合过程的通用术语。前缀‘re-’ = ‘又’或‘新的’。       

    Redundant                冗余的       
    In normal English, redundant = repetitive.  The genetic code is called redundant because several codons may code for one amino acid.                在日常英语中,redundant = 重复的。遗传密码是冗余的,因为存在几个密码子编码同一种氨基酸的现象。       

    Release factor                释放因子       
    A protein that binds to stop codons, releasing ribosomes, tRNA, and mRNA from each other.                一种结合到终止密码子上的蛋白质,能将核糖体、tRNA和mRNA各自释放出来。       

    Replication bubble                复制泡       
    Separation of single-strands in DNA helix creates a somewhat circular opening where DNA replication can take place.                在DNA螺旋中单链分离产生的有点像环形的开口,在这儿可以发生DNA复制。       

    Replication fork                复制叉       
    A separation of single strands that is the site for one direction of DNA replication.  In normal English, a ‘fork’ = the site where a larger path splits into smaller paths.  At the replication fork, the thick double-stranded DNA molecule splits into two single-stranded DNA molecules.                单链分离产生的可以向一个方向复制DNA的位点。在日常英语中,‘fork’ = 一条大路分成几条小路的地点。在复制叉处,粗的双链DNA分子被分成两条单链DNA分子。       

    Replicative transposition                复制型转座       
    A transposition mechanism in which the original transposon is replicated, and the copy is inserted into a new site in the DNA.                一种转座机理,其中原始的转座子被复制,转座子的拷贝被插入到一个DNA的新位点中。       

    Restriction endonucleases                限制性内切核酸酶       
    Enzymes that cut DNA at specific sequences inside the molecule (see endonuclease).  The term ‘restriction’ comes from the fact that these enzymes were originally discovered because they restrict the entry of viruses into bacteria, by cutting viral DNA.  These proteins are sometimes simply called ‘restriction enzymes.’                在分子内的特异序列位置切割DNA的酶(参照‘内切核酸酶’)。‘限制’一词来源于这样的事实:这些酶最初在细菌中发现,它们的功能是通过切断病毒的DNA而限制(restrict)病毒进入。这些蛋白质有时就被简单地称为‘限制酶’。       

    Reverse genetics                反向遗传学       
    Form of genetics/molecular biology research in which a gene is first identified, and then the function/phenotype associated with the gene is explored.                一种遗传学/分子生物学研究的形式,它先鉴定出一个基因,之后探索与这一基因相关的功能/表型。       

    Reverse transcription                反转录       
    The process of making DNA from RNA.  This is the reverse of transcription.                从RNA生产DNA的过程。这是一个与转录相反的过程。       

    Reverse transcriptase                反转录酶       
    Enzyme that performs reverse transcription.                行使反转录功能的酶。       

    Ribonucleases                核糖核酸酶       
    Enzymes that cleave ribonucleic acid (RNA).                切割核糖核酸(RNA)的酶。       

    Ribonucleic acid (RNA)                核糖核酸(RNA)       
    A nucleic acid made by polymerization of ribonucleotides.                通过聚合核糖核苷酸产生的核酸。       

    Ribonucleotides                核糖核苷酸       
    Nucleotides containing the sugar ribose.                含有核糖的核苷酸。       

    Ribosome                核糖体       
    Large macromolecular complexes comprised of RNA (ribonucleic acid) and protein.                由RNA(ribonucleic acid)和蛋白质组成的大型大分子复合体。       

    RNA interference (RNAi)                RNA干涉(RNAi)       
    A process that uses siRNA or miRNA to induce degradation of a target mRNA.  The process ‘intereferes’ with the normal stability of mRNA.                一种应用siRNA或miRNA诱导目标mRNA降解的过程。该过程‘干涉’了mRNA的正常稳定性。       

    RNA polymerase                RNA聚合酶       
    Enzyme that polymerizes RNA strands.                聚合RNA链的酶。       

    RNA polymerase core                RNA聚合酶核心       
    The smallest set of RNA polymerase subunits required for transcription.  Unable to initiate transcription correctly.                对转录而言需要的RNA聚合酶亚基的最少组合。不能正确地启动转录。       

    RNA polymerase holoenzyme                RNA聚合酶全酶       
    The whole set of RNA polymerase subunits, able to initiate transcription at the promoter.                RNA聚合酶亚基的全套组合,能够在启动子的位置启动转录。       

    rRNA                rRNA       
    RNA that is directly used to make ribosomes.  Is not translated.                直接用来生产核糖体(ribosomes)的RNA。它不被转译。       

    Rudder                方向舵       
    Part of the RNA polymerase structure that ensures separation of DNA strands in the transcription bubble.  In normal English, a rudder is that flat, thin part of a boat that is used to steer.  The RNA polymerase rudder somewhat resembles a boat rudder in shape.                RNA聚合酶结构的一部分,用来确保DNA双链在转录泡中分开。在日常英语中,rudder是小船上用来掌握方向的扁平、薄的部件(即船舵)。RNA聚合酶方向舵的形状看起来有点像小船上的舵。
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    地板
    发表于 2009-8-11 15:38 | 只看该作者

    谢谢了

    THANK YOU LZ!
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    发表于 2009-9-15 12:06 | 只看该作者
    感谢啊
    :)
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    发表于 2009-10-22 02:10 | 只看该作者
    不知道怎样表达感谢!!!!!!!
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    发表于 2009-10-22 20:07 | 只看该作者
    无以言语,只有感谢罗
    加油
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